lack of association between single nucleotide polymorphism rs10818488 in traf1/c5 region and rheumatoid arthritis in iranian population.

the association of rs10818488 snp located in traf1/c5 region with rheumatoid arthritis (ra), has been picked up by genome-wide association studies. independent studies in different populations revealed inconsistent results. the aim of this study was to investigate the possible association of this snp with ra in iranian population. a total of 362 cases and 422 healthy controls were recruited in this study. genomic dna was extracted from whole blood and the genotyping was performed by pcr-rflp (polymerase chain reaction– estriction fragment length polymorphism). a set of genotypes was confirmed by sequencing. genotype and allele frequencies were compared between the case and control groups. analysis indicated a higher frequency of a allele in cases, although the difference was not statistically significant (chi-square=2.8, p=0.09). comparison of genotype frequencies, revealed higher frequencies of aa and ag genotypes in case group but statistically the difference was not significant (chi-square=2.72, p=0.25).  these findings suggest that the rs10818488 in traf1/c5 region is not associated with rheumatoid arthritis in iranian population.